CREATINE NITRATE – Benefits – Side effects

CREATINE NITRATE - Benefits - Side effects


Creatine nitrate: Discover all the benefits of creatine nitrate, one of the forms with the highest absorption and bioavailability.

What is creatine, and what benefits does it offer?

Creatine is a molecule made up of three amino acids, l-arginine, glycine, and l-methionine, which is found naturally in the skeletal muscle of our body and foods such as beef, chicken, or rabbit. However, approximately 30% of the creatine contained in these foods destroys through cooking.

In our body, creatine behaves as a stored form of cellular energy or ATP, available faster than glucose and allows cells to withstand great intense efforts.

Creatine store as phosphocreatine. Exercise releases cellular energy, producing a more significant gain in strength, providing more excellent permeability to the muscle (which implies a greater blood supply), and improves anabolic processes.

It is one of the most used supplements in the sports field since it is an excellent aid to increase sports performance and develop muscle tissue.

What is creatine nitrate?

The first creatine supplement that was designed was creatine monohydrate. All the formulas developed from that moment on had the objective of improving the absorption of this compound by the body.

Creatine nitrate is made up of a nitrate bound to a creatine molecule. It is one of the most soluble and bioavailable formulas, producing excellent hydration within cells, not in the external environment.

Creatine Nitrate vs. Creatine Monohydrate: Which Is Best For You?

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CREATINE NITRATE – Benefits – Side effects

Another essential characteristic of creatine nitrate is that it stimulates nitric oxide production not through arginine but through nitrate itself and without the need to activate the enzyme NOS (arginine-nitric oxide synthase).

Creatine nitrate uses the “nitrate-nitrite-nitric oxide” pathway to produce nitric oxide, and this same pathway regulates the tissue’s reaction to hypoxic conditions (lack of oxygen) typical of anaerobic exercise.

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Creatine nitrate supplementation

Creatine supplementation has been extensively studied and has also shown to be very safe if the maximum does not exceed, causing only mild stomach upset in some cases.

Creatine can increase body weight, but this is only due to a higher hydration level, returning the importance to normal once supplementation has been interrupted.

It is essential to follow all the recommendations specified on the product labeling since not all supplements work with the same type of creatine or use the same concentrations.

Creatine nitrate is one of the most potent creatine formulas, being one of the most effective supplements to increase athletic performance and gain muscle tissue.

Here are 7 science-based benefits of creatine

The nitrate creatine uses via ” nitrate -nitrito-nitric oxide” for the production of nitric oxide and the same pathway regulates tissue reaction to hypoxic conditions (lack of oxygen) typical anaerobic exercise.

  1. Helps muscle cells produce more energy.
  2. Supports many other functions in muscles.
  3. Improves high-intensity exercise performance.
  4. Speeds muscle growth.
  5. May help with Parkinson’s disease.
  6. May fight other neurological diseases.
  7. May lower blood sugar levels and fight diabetes.

Creatine Nitrate vs. Creatine Monohydrate: Which Is Best For You?

The Power of Creatine Nitrate

When we talk about creatine, everyone usually refers to creatine monohydrate; it is the most widely used creatine by many athletes, and it is the most researched. But now, another creatine has come to light, and it is known as creatine nitrate

It is creatine attached to nitrate, a polyatomic ion, rather than a single water molecule like creatine monohydrate.

There’s a reason creatine has had its niche in the sports nutrition market for over 20 years, and it remains the number one supplement on the market besides the popular protein powder. This time creatine nitrate appeared due to its new structure (creatine attached to the nitrate anion), which has its scientific explanation.

So what does this mean? Makes it more bioavailable? More soluble in water? Does it provide a better muscle pump?

The companies claim that it is much more soluble in water, and for specialists, this is very credible because the research takes the characteristics of the nitrate family, which is very soluble. 

The point is that water solubility has nothing to do with bioavailability and although there are no long-term sustainable studies citing that if creatine nitrate is more bioavailable than creatine monohydrate, there is a cause for its design and distribution. among athletes who want to feel a spectacular pump and much more strength in each repetition.

Getting to know creatine nitrate

The Creatine Nitrate is a new form of creatine in which the base molecule creates standard creatine monohydrate, which is now in a group of nitrate (attached creatine nitrate anion). This means that the creatine compound is now bound to a nitrogen base, creating creatine nitrate; the reason for the binding of the nitrate group to creatine is possible to help increase the solubility of the compound within the body in post-consumption.

By increasing the solubility of creatine, creatine nitrate allows a higher concentration of creatine to be absorbed by the body using the same 5g dose of creatine that most athletes recommend. However, as it is much more easily absorbed and the dose is concentrated, the athlete will be able to reduce the daily dose to around just 2.5 g of creatine nitrate.

Although we are still at the beginning of the research, current studies show that creatine monohydrate is absorbed into the body at rates as high as 98%. This means that a mere 2% of the creatine consumed is not used and will end up as a waste by-product; this is a very low amount of garbage and so low that there is really no reason to think it is a waste.

However, studies on creatine nitrate show that 100% of creatine is absorbed without losing the power it represents, although the nitrate group provides an extra dose that many want when training hard.

  • Creatine itself is one of the most researched and effective natural compounds for increasing body mass, strength, and power, as well as reducing pain and fatigue.
  • Nitrates induce you to get such an insane muscle pump when you make a submaximal effort or train hard in every intense set.

There is research done in Texas A and M that clearly demonstrates the effectiveness of creatine nitrate in athletes, resulting in a substantial improvement in power and overall workload.

  • First of all, nitrates are powerful vasodilators in the body, leading to increased blood flow to the muscles, and this increased blood flow results in bigger, more dramatic, and long-lasting pumps.
  • Second, nitrate supplementation exerts some cardiovascular benefits in terms of lowering blood pressure. As if that weren’t enough, nitrates also enhance athletic performance, lowering the body’s oxygen consumption during intense reps.

Uses of creatine

During short-term, high-intensity exercise, such as weight lifting or sprinting, phosphocreatine converts to ATP, the primary energy source within the human body.

The appeal of creatine is that it can increase lean muscle mass and improve athletic performance, especially during short-duration, high-intensity sports (such as high jump and weight lifting).

Creatine is most commonly used to improve exercise performance and increase muscle mass in athletes and older adults. Permitted by the International Olympic Committee, the National Collegiate Athletic Association (NCAA), and professional sports.

I also taken by mouth for creatine deficiency syndromes affecting the brain, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), depression, diabetes, fibromyalgia, Huntington’s disease, idiopathic inflammatory myopathies, Parkinson’s disease, diseases of the muscles and nerves.

Multiple sclerosis, muscle atrophy, muscle cramps, breathing problems in babies while sleeping, head trauma, Rett syndrome, gyratory atrophy, inherited disorders affecting the senses and movement, schizophrenia, muscle breakdown of the spine.

It takes by mouth to slow the progression of amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), osteoarthritis, rheumatoid arthritis, McArdle’s disease, and various muscular dystrophies. Creatine can be use applied to the skin to slow skin aging.

Creatine Nitrate vs. Creatine Monohydrate: Which Is Best For You?

Security issues

Creatine is safe when taken by mouth for up to 5 years. When taken by mouth in high doses, creatine is not secure.

There is some concern that it could harm your kidney, liver, or heart function. However, a connection between high doses and these adverse effects has not been proven.

It can also cause stomach pain, nausea, diarrhea, and muscle cramps.

Creatine causes muscles to remove water from the rest of your body, so be sure to drink more water to compensate for this characteristic of this amino acid.

Also, if you take creatine, not exercising in a hot environment could cause you to become dehydrated.

Many people who use creatine gain weight. This is because creatine causes muscles to retain water, not because strength is developing.

There is some concern that combining creatine with caffeine and the herb ephedra (also called Ma Huang) could increase the likelihood of severe side effects, such as stroke.

Creatine may cause an irregular heartbeat in some people and a skin condition called pigmented purpuric dermatoses.

Creatine combinations with other medications

Taking high doses of creatine could damage the kidneys.

Taking creatine with other medications that can damage the kidneys could increase the risk of kidney damage.

Some of these medications that can damage the kidneys include:

  1. Cyclosporine (Neoral, Sandimmune)
  2. Aminoglycosides, including amikacin (Amikin)
  3. Gentamicin (Garamycin, Gentak, others)
  4. Tobramycin (Nebcin, others)
  5. Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene)

The side effects of creatine include:

Most studies have found no significant side effects at doses used for up to 6 months. It is considered safe when used short term. Creatine can lower blood sugar levels. Caution is advised in people with diabetes or hypoglycemia and those taking drugs, herbs, or supplements that affect blood sugar.

  1. Weight gain.
  2. Muscle cramps.
  3. Muscle strains and pulls.
  4. Stomach ache.
  5. Diarrhea.
  6. Dizziness.
  7. Arterial hypertension.
  8. Liver dysfunction

Blood glucose levels may need to be monitored by a qualified physician and may adjust medications. Creatine can cause high blood pressure. Caution is advised in people taking medications or herbs and supplements that raise blood pressure. Why Does Beta-Alanine Make You Itch

It should use with caution in people with:

  • Deep venous thrombosis
  • Electrolyte disturbances
  • Gastrointestinal disorders
  • Irregular heartbeat
  • Kidney stones
  • Liver disease
  • Migraines
  • Musculoskeletal disorders
  • Neurological diseases
  • Neuromuscular disorders
  • Orthostatic hypotension (low blood pressure when standing up)
  • People who participate in activities such as running, swimming, and gymnastics
  • Psychiatric disorders
  • Seizures
  • Skin disorders
  • Athletes who can combine dehydration regimens (diuretics, sweating).

It should use with caution in people taking drugs excreted through the kidneys or agents toxic to the kidneys, including:

  • Aminoglycosides
  • Gallium nitrate
  • Tacrolimus and valacyclovir
  • Agents that increase urination (diuretics)
  • Agents toxic to the liver
  • Caffeine and Caffeine-Containing Medications
  • Chemotherapy
  • Cholesterol-lowering agents
  • Cimetidine
  • Digoxin
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen
  • Probenecid
  • Trimethoprim.

It should avoid in people with impaired kidney function, dehydration, or bipolar disorder. It should prevent in combination with ephedra. Avoid with known allergy or sensitivity to creatine.

CREATINE NITRATE - Benefits - Side effects
CREATINE NITRATE – Benefits – Side effects

The US Food and Drug Administration (FDA) has advised consumers to consult their physician before using creatine. There is concern that athletes may exceed recommended doses; the secondary effects are not apparent in these conditions.

Creatine Nitrate vs. Creatine Monohydrate: Which Is Best For You?


Creatine is a naturally occurring amino acid found in the body, primarily in the muscles and brain. It create naturally in the human body in the kidneys, pancreas, and liver.

The nitrate creatine is used via ” nitrate -nitrate-nitric oxide” to produce nitric oxide, and the same pathway regulates tissue reaction to hypoxic conditions (lack of oxygen) typical anaerobic exercise.

It is stored primarily in the muscles, but about 1.5 – 2% of the body’s creatine converts to creatinine. It found in the diet of red meat and seafood. It can also create in the laboratory.

CREATINE NITRATE – Benefits – Side effects

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