vanady What is Vanadyl sulfate good for?
This mineral can help bodybuilders significantly. Studies have shown that vanadium sulfate enhances insulin-controlled anabolic processes. Like testosterone and the growth hormone HGH, insulin is a powerful anabolic agent. The vanadyl sulfate copies the effects of insulin (insulin like effect) causing the transport of glucose and amino acids within the cell to a greater degree than would normally occur without the use of the same. This creates a perfect anabolic environment for the growth of the muscle that has just been trained, making it denser and more voluminous.
It is important to keep fat intake to a minimum while using vanadium sulfate .
The recommended dose of vanadium sulfate is 30-45 mg per day divided into 3 or 4 daily administrations after meals to avoid intestinal disturbances and hypoglycemia. A safe way is to cycle the use of vanadium sulfate: 8 weeks of administration and 2 weeks of interval (just to ensure that you get the required result of the mineral).
For anyone that’s ever taken a chemistry course, you’ve probably heard about the element vanadium (or maybe even vanadyl sulfate).
But in the weight loss and fitness world, the look people give you when you say vanadyl sulfate is the same look that they’ll give you when you say that weight training for women will make them bulky. Same reaction, different concept, but you get the point.
Most people haven’t run into vanadyl sulfate in supplement form and have no idea why it may benefit them. So, if you fall into that camp, this article is for you. We’re giving you an overview of vanadyl sulfate and if it’s something worth adding to your supplement stack—especially if you’re looking to drop a few pounds.
What is Vanadyl Sulfate?
Fun fact: Vanadium was actually named for the Norse goddess of beauty, Vanadis, because of its beautiful colors, but now it’s widely used as an alternative medicinal supplement.
Vanadium is a trace element that’s said to be essential for proper cell function and development and exists in two forms: vanadyl sulfate, the most common form, and vanadate.
As a trace mineral, vanadium is required in tiny amounts to support certain biological functions, but there’s not yet a conclusive decision as to whether vanadium is actually ‘essential.’
But if it’s not essential, what’s the point of taking it?
The Benefits Of Vanadyl Sulfate
- Formula: VOSO4
- Molar mass: 163 g/mol
- Melting point: 221°F (105°C)
- Solubility in water: Soluble
- Flash point: Non-flammble
- Colors: blue
1. Blood Sugar Control
As one of the most common conditions globally, type 2 diabetes affects a staggering 462 million people, which corresponds to over 6% of the world’s population. And with more than a million deaths each year, it’s the ninth leading cause of mortality.
So, what can you do about it?
It turns out that vanadium compounds may improve glucose homeostasis and enhance insulin sensitivity. While most studies are conducted on animals, the few human studies suggest a beneficial role. The mechanism behind how vanadyl sulfate regulates glucose still isn’t completely understood.
Some studies suggest that vanadate salts help to restore normal insulin receptor binding and to decrease the activity of certain enzymes, while others indicate that vanadium helps to restore the hepatic activity of key glycolytic and gluconeogenic enzymes, including glucose-6-phosphatase; this effect is of particular interest because chronic hyperglycemia has been shown to stimulate the body’s production of glucose by up-regulating the glucose-6-phosphatase complex, which is the final step before glucose is released by the liver.
In one study specifically, six weeks of treatment with vanadyl sulfate in patients with type 2 diabetes improved glycemic control by reducing basal endogenous glucose production and enhancing skeletal muscle insulin sensitivity. This pathway could be the potential key for achieving weight loss with vanadyl sulfate.
2. Cholesterol and Lipid Profile
There’s no shortage of nutritional supplements designed to improve heart health and manage cholesterol levels and lipid profile. One of those that often isn’t talked about is vanadium, and studies show that it could offer some benefits.
It’s well established that lipid and lipoprotein abnormalities play a serious role in the pathogenesis and progression of conditions like atherosclerosis, cardiovascular disease, and diabetes. But while human evidence is still lacking, research on rodents has found an interesting link.
Previous studies suggest that long-term supplementation of vanadium in rats resulted in decreased total cholesterol levels; other studies found that vanadium significantly reduced triglyceride levels.
In humans, however, one cross-sectional study concluded that vanadium is associated with increased HDL-C and apoA-I levels, along with a decrease in atherogenic index values (TC/HDL-C, LDL-C/HDL-C, and apoB/apoA-I)—all important markets for cholesterol levels.
Does It Help With Weight Loss?
If you’re hoping for vanadium to stimulate some super-charged fat-burning pathway in your body, you can think again.
Instead, vanadyl sulfate may contribute indirectly to weight loss by regulating glucose levels to prevent blood sugar spikes and/or the negative side effects of high blood sugar and diabetes on weight.
Here’s a quick side note to help you understand how insulin resistance and imbalanced blood glucose can contribute to weight gain:
Insulin is a hormone that regulates blood glucose. It’s released by the pancreas when glucose enters the bloodstream to enable glucose uptake by cells. If you’re eating a diet that’s high in refined carbohydrates (or high in carbs in general), your body is constantly releasing insulin to manage blood glucose levels.
When your cells are constantly being bombarded with insulin, at some point, they may become dysfunctional. They stop responding to insulin and stop allowing glucose to enter cells.
As a result, you’re left with chronically high blood sugar, high insulin, and insulin resistance. It’s a disastrous trio, especially where weight is concerned.
By nature, insulin is a fat-storage hormone. When your cells are not taking up glucose, insulin will cause glucose to be stored as fat.
And when you have too much insulin circulating in the blood in combination with insulin resistance, it can cause damage to your blood vessels.
See how it all links together?
But when you can improve insulin sensitivity and glucose uptake with something like vanadyl sulfate—combined with a healthy diet and physical activity, of course—you can drastically improve your body’s ability to utilize and store energy and also lose weight in the process.
There’s another aspect to it:
Studies show that because insulin may inhibit hypothalamic neuropeptide Y (NPY), which is linked to regulating appetite, and boost leptin secretion in adipose tissue, changes in appetite may be mediated by vanadium intake 6.
One rodent study found that vanadium supplementation may increase insulin sensitivity in adipose tissue, decrease appetite, and reduce body fat by reducing NPY levels.
Vanadyl sulfate Chemical compound
To investigate the efficacy and mechanism of action of vanadium salts as oral hypoglycemic agents, 16 type 2 diabetic patients were studied before and after 6 weeks of vanadyl sulfate (VOSO4) treatment at three doses. Glucose metabolism during a euglycemic insulin clamp did not increase at 75 mg/d, but improved in 3 of 5 subjects receiving 150 mg VOSO4 and 4 of 8 subjects receiving 300 mg VOSO4.
Basal hepatic glucose production (HGP) and suppression of HGP by insulin were unchanged at all doses. Fasting glucose and hemoglobin A1c (HbA1c) decreased significantly in the 150- and 300-mg VOSO4 groups. At the highest dose, total cholesterol decreased, associated with a decrease in high-density lipoprotein (HDL). There was no change in systolic, diastolic, or mean arterial blood pressure on 24-hour ambulatory monitors at any dose.
There was no apparent correlation between the clinical response and peak serum level of vanadium. The 150- and 300-mg vanadyl doses caused some gastrointestinal intolerance but did not increase tissue oxidative stress as assessed by thiobarbituric acid-reactive substances (TBARS).
In muscle obtained during clamp studies prior to vanadium therapy, insulin stimulated the tyrosine phosphorylation of the insulin receptor, insulin receptor substrate-1 (IRS-1), and Shc proteins by 2- to 3-fold, while phosphatidylinositol 3-kinase (PI 3-kinase) activity associated with IRS-1 increased 4.7-fold during insulin stimulation (P = .02).
Following vanadium, there was a consistent trend for increased basal levels of insulin receptor, Shc, and IRS-1 protein tyrosine phosphorylation and IRS-1-associated PI 3-kinase, but no further increase with insulin. There was no discernible correlation between tyrosine phosphorylation patterns and glucose disposal responses to vanadyl.
What is Vanadyl sulfate good for?
While glycogen synthase fractional activity increased 1.5-fold following insulin infusion, there was no change in basal or insulin-stimulated activity after vanadyl. There was no increase in the protein phosphatase activity of muscle homogenates to exogenous substrate after vanadyl. Vanadyl sulfate appears safe at these doses for 6 weeks, but at the tolerated doses, it does not dramatically improve insulin sensitivity or glycemic control.
Friends, Vanadyl modifies proteins in human skeletal muscle involved in early insulin signaling, including basal insulin receptor and substrate tyrosine phosphorylation and activation of PI 3-kinase, and is not additive or synergistic with insulin at these steps. Vanadyl sulfate does not modify the action of insulin to stimulate glycogen synthesis. Since glucose utilization is improved in some patients, vanadyl must also act at other steps of insulin action.
Vanadyl sulfate (VOSO4) is an oxidative form of vanadium that in vitro and in animal models of diabetes has been shown to reduce hyperglycemia and insulin resistance. Small clinical studies of 2- to 4-week duration in type 2 diabetes (T2DM) have led to inconsistent results.
Is it safe to take vanadyl sulfate?
What are the benefits of vanadium, which is included in your daily vitamin/mineral supplement? I’ve read about potential toxicity even at low doses and also that high blood levels of vanadium are noted in people who have manic episodes or suffer from depression. Should I avoid taking this as a supplement as I already suffer from mild depression?
Vanadyl sulfate appears safe at these doses for 6 weeks, but at the tolerated doses, it does not dramatically improve insulin sensitivity or glycemic control.
Vanadium is a micronutrient found naturally in mushrooms, shellfish, black pepper, parsley, dill, grain and grain products. It exists as both vanadyl sulfate, the form most commonly used in supplements, and vanadate. We’re not sure exactly how much vanadium the body needs; the typical diet provides less than 30 micrograms daily.
In the past, vanadium was promoted as a cure for various illnesses at doses ranging from 15 to 100 mg of vanadyl sulfate daily – that’s 1,000 times the dietary dose, but no scientific evidence supports the use of these large amounts, which may be toxic. The small amounts contained in most multivitamin/mineral products – 10 micrograms in my formula – are too low to raise concern about toxicity.
A few small studies have indicated that higher doses of vanadium can improve insulin sensitivity and reduce blood sugar in people with diabetes; however, the dosage and long-term safety of this strategy has not been established.
Some animal studies have suggested that vanadyl sulfate may help lower blood pressure, but no human studies have been done. Unless a benefit is proved, I see no reason to take vanadium for this purpose. Nor is there any evidence demonstrating that vanadium can improve athletic performance and increase muscle mass, even though vanadium supplements are widely used for these reasons.
As far as manic depression (bipolar disorder) is concerned, some evidence suggests that blood levels of vanadium may be elevated during manic episodes and also high during depression, particularly when it is accompanied by delusional thoughts or other symptoms of psychosis.
I’ve seen recommendations that a low vanadium diet may be helpful for those with bipolar disorder, but considering that the body absorbs only about five percent of the vanadium in the food we consume, I’m not sure how you could get intake any lower.
In any event, I’m not convinced that there’s a connection between vanadium and mental disturbance. Even if there were, I do not think the small amounts of Vanadyl sulfate in multivitamin/mineral supplements are an issue for those with mild depression.
Is vanadium harmful to humans?
Vanadium is a metallic element that occurs in six oxidation states and numerous inorganic compounds. Some of the more important compounds are vanadium pentoxide (V2O5), sodium metavanadate (NaVO3), sodium orthovanadate (Na3VO4), vanadyl sulfate (VOSO4), and ammonium vanadate (NH4VO3). Vanadium is used primarily as an alloying agent in steels and non-ferrous metals (ATSDR, 1990). Vanadium compounds are also used as catalysts and in chemical, ceramic or specialty applications.
Friends, Vanadium compounds are poorly absorbed through the gastrointestinal system (0.5-2% of dietary amount) (NRCC, 1980; ICRP, 1960; Byrne and Kosta, 1978), but slightly more readily absorbed through the lungs (20-25%) (ICRP, 1960; Davies and Bennett, 1983). Absorbed vanadium is widely distributed in the body, but short-term localization occurs primarily in bone, kidneys, and liver (Vouk, 1979; Roshchin et al., 1980; Parker et al., 1980; Sharma et al., 1980; Wiegmann et al., 1982).
In the body, vanadium can undergo changes in oxidation state (interconversion of vanadyl (+4) and vanadate (+5) forms) and it can also bind with blood protein (transferin) (Harris et al., 1984). Vanadium is excreted primarily in the feces following oral exposures and primarily in the urine following inhalation exposures (Tipton et al., 1969; ATSDR, 1990).
At common concentrations, vanadium is non-toxic. The main source for potentially toxic effects caused by vanadium is exposure to high loads of vanadium oxides in the breathing air of vanadium processing industrial enterprises. Vanadium can enter the body via the lungs or, more commonly, the stomach.
How much vanadyl sulfate should I take?
Adult: 10 mg vanadyl sulfate yields 2 mg vanadium. The body contains between 20-25 mg and a regular diet provides
There is not enough safety information available about the risks of vanadium to be recommended as a safe supplement.
Dosage of Vanadium:
Typical dosage range: 50-100 mcg/day
Dosage Considerations – Should be Given as Follows:
- 10 mg vanadyl sulfate yields 2 mg vanadium
- The body contains between 20-25 mg and a regular diet provides about 2 mg/day
- Daily diet normally provides enough to meet requirements
- Sources of vanadium: Dill, pepper, eggs, radishes, vegetable oils, buckwheat and oats
- Pediatric: Not established
How does vanadium help with diabetes?
Vanadium seems to decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking vanadium along with diabetes medications might cause your blood sugar to go too low.
There is some evidence that high doses of vanadyl sulfate (100 mg daily, providing 31 mg elemental vanadium) might improve the way people with type 2 diabetes use insulin, the hormone that processes sugar. The study suggested that high-dose vanadium might lower blood sugar in people with type 2 diabetes.
Vanadyl sulfate isn’t a miracle mineral for weight loss. It’s not going to rev your metabolism and help you shed fat in your sleep like a fat burner, but it may indirectly support weight loss by improving insulin sensitivity and glucose uptake.